TB-500 (Thymosin Beta-4)

TB-500 is a synthetic version of the active region of Thymosin β4, a naturally occurring 43-amino-acid actin-sequestering peptide. The principal mechanism in the literature is binding to G-actin via the conserved actin-binding motif (KLKKTET), regulating cytoskeletal dynamics and enabling cell migration during tissue repair.

Secondary mechanisms include upregulation of laminin-5 and integrin expression supporting endothelial cell migration, suppression of inflammatory cytokines in injury models, and angiogenic effects mediated through pathways overlapping with VEGF signaling.

Like BPC-157, the evidence base is preclinical. Human work to date is limited to early-phase trials in dry-eye and dermal indications conducted with the parent Thymosin β4 sequence rather than TB-500 specifically.

Research Applications

• Preclinical wound-healing and dermal repair research.
• Cardiac repair models post-myocardial injury.
• Corneal and ocular surface healing research (parent compound).
• Comparative regenerative research alongside BPC-157.